Pleiotropic roles of metallothioneins in osteoarthritis(oa) pathogenesis
نویسندگان
چکیده
منابع مشابه
Pleiotropic roles of metallothioneins as regulators of chondrocyte apoptosis and catabolic and anabolic pathways during osteoarthritis pathogenesis
OBJECTIVE The zinc-ZIP8-MTF1 axis induces metallothionein (MT) expression and is a catabolic regulator of experimental osteoarthritis (OA) in mice. The main aim of the current study was to explore the roles and underlying molecular mechanisms of MTs in OA pathogenesis. METHODS Experimental OA in mice was induced by destabilisation of the medial meniscus or intra-articular injection of adenovi...
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ژورنال
عنوان ژورنال: Osteoarthritis and Cartilage
سال: 2017
ISSN: 1063-4584
DOI: 10.1016/j.joca.2017.02.262